STREET 2 GYM

MOLICURE

$59.99

STREET 2 GYM

MOLICURE

$59.99

Description

MOLICURE: 

14 Ingredients = 14 Clinical Trials

Possibly the most scientifically advanced post workout recovery agent ever created!

 

CLINICALLY TRIALED INGREDIENTS. LETS TAKE A LOOK AT THEM AND WHAT THEY DO. 

Nicotinamide Mononucleotide (NMN) Peptide:

        Benefits Overview:

  • Boost Immune System
  • Enhance Muscle Endurance and Strength
  • Normalizes Hormone Levels
  • Increase lean Muscle Mass while decreasing body fat
  • Anti-Aging (RNA & DNA cellular repair)
  • Increase Neurological Function
  • Improve Heart Health
  • Decrease Risk of Diabetes & Metabolic Syndrome
  • Decrease Oxidative Stress
  • Normalize Circadian Rhythms
  • Reduce Chronic Fatigue
  • Reduce Chronic Inflammation
  • Prevention of Type 2 Diabetes
  • Repair DNA at the intracellular level
  • Weight Loss reverses insulin resistance, improves glucose tolerance, and ameliorates mitochondrial dysfunction

According to a 2018 study by Dr. Satchidananda Panda on time-restricted feeding, longevity has much to do with when you eat as opposed to what you eat. There are processes in the body that diet, exercise, calorie restriction, and intermittent fasting activates that make us healthier and live longer. This is where it gets even more interesting! Scientists have figured out a large part of the chemistry involved in the above, and are now using β-Nicotinamide Mononucleotide (NMN), a molecule, to mimic the processes. According to scientists, when NMN is added to diet and exercise, it performs even better in fighting off aging without leaving behind any side effects.  If you’ve committed to anti-aging therapy, there is a chance that you already have a diet plan in place, complete with a workout regime and probably a few supplements. Many people in the anti-aging field today supplement with NMN to augment what they cannot get naturally. This brings us to the question: what is NMN? It all happened about 20 years ago at M.I.T (Massachusetts Institute of Technology) when Leonard Guarente, a biology professor, and a team of other scientists discovered SIRT1 genes (Sirtuins) in yeast. Sirtuins control aging: seven of them are found in humans and five in yeast. Essentially, they protect all organisms on the planet, including humans, from deterioration and disease. They work amongst many cellular pathways that control cell death, turn anti-aging genes on and off, help repair DNA, and regulate metabolism. SIRT 1 is one of the four longevity pathways.  When more of these genes were put in organisms, the organisms’ lifespans extended by 5 to 20 percent. It was with this discovery that scientists began mimicking the genes using molecules. One of the molecules they used was NMN and the other, resveratrol.  NMN is a Vitamin B3 (niacin) derivative. It occurs naturally and can be made from dietary sources such as fruits, milk, and vegetables. In the body, NMN is used to generate nicotinamide adenine dinucleotide (NAD+), a powerful and essential molecule that is found in every cell of the body. Believe it or not, if NAD+ levels in your body drop to zero, you’d be dead in about 30 seconds. Also, and probably the most important when it comes to longevity and the fight against aging, NAD+ plays a crucial role in activating Sirtuins. As a matter of fact, without NAD+, the SIRT1 genes can’t work and perform their role of protecting our bodies from deterioration and disease. Unfortunately, as we age, the levels of NAD+ fall. By the time we are 50 years old, for most of us, our NAD+ levels are about half of what they were when we were 20. This decrease in NAD+  interferes with SIRT1’s ability to defend our bodies and slow down the aging process. For many years, it was thought that the NAD+ molecules were too large to be taken directly and needed to be raised using a precursor such as NMN. Recently, it has been found that NAD+ can cross the blood-brain barrier and to reach the hypothalamus if taken sublingually. It can boost NAD+ levels in this gland which will benefit the entire body because it controls the metabolism. It’s can also be a potential supplement to help those who have metabolic disorders because of decreased NAD+ levels in the hypothalamus. NMN, on the other hand, elevates NAD+ levels in cells throughout the body and is a better supplement to take to boost your overall NAD+ levels and slow aging. According to clinical trials, NMN supplements boost NAD+ to youthful levels. Making the NAD+ molecule available to SIRT1 genes enhances their ability to protect the body against disease and deterioration. As more studies are being conducted, researchers are finding that NAD+ also has an important role to play in regulating our immune systems. In addition, studies have shown that NAD+ can trigger an immune system response to protect the body from a coronavirus such as COVID-19. A review published March 23, 2020 by Isfahan University of Medical Sciences provides evidence that low NAD+ levels could be tied to higher severity and morbidity rates in the COVID-19 pandemic “In the depicted molecular pathology pathway of COVID-19, almost all procedures lead to or originate from NAD+ depletion.  Consumption of NAD in large amounts to repair DNA decreases ATP levels leading to impairment of all activities and integrity of the cell.” “Taking NAD+ or Vitamin B3 plus L-tryptophan could replenish NAD+ and serotonin and recover the body toward hemostasis.” They’ve also found that macrophages (a type of white blood cell that eats potential invaders such as bacteria, fungi, parasites, and viruses) use a pathway synthesized by NAD+ to ensure cell survival and control inflammation. All in all, studies are indicating that NMN and the resulting increased levels of NAD+ can play an important role in helping our bodies fight off infections and bacteria. In other words, it has the potential to boost our immune systems and help them during times of infection and illness. What is NMN good for? It’s almost, if not totally impossible, to discuss NMN benefits without looking at the longevity pathways. There are four main longevity pathways identified in organisms including humans: When activated, each of these pathways regulates lifespan and aging. NMN together with resveratrol work through the SIRT1 Pathway to stop or backpedal the effects of aging. Below are the specific benefits of NMN in activating the body’s defenses against aging. NMN boosts energy supply in aging cells Cells take in and process fuel to power their functions. As you age they lose this ability, forcing them into a condition known as cellular senescence or biological aging that comes with other detrimental effects. Previously, NAD+ which is a key element of the cell’s fuel supply was thought to be the only route through which NMN can contribute to cell energy. However, a groundbreaking Washington University School of Medicine study published in the Nature Metabolism journal shows that NMN can be delivered directly into cells without conversion to NAD+. This direct and faster delivery is possible with the help of a mystery transporter protein called Slc12a8. Another interesting discovery is that Slc12a8 is automatically dialed up by cells when NAD+ levels fall. This means that supplementing with NMN gives your cells a much quicker path to refuel and promotes cell division and growth. NMN helps in fighting metabolic diseases As you age, conditions such as diabetes, obesity, dyslipidemia, and non-alcoholic fatty liver disease (NAFLD) become prevalent. They are caused by a reduction in NAD+ levels. NMN works through the salvage pathway to boost the levels of NAD+ thereby ameliorating these and other metabolic diseases. Imagine being 90 and disease-free. You can literally run around with your grandchildren like a 50-year-old! It is possible to achieve this level of youthfulness with NMN supplements. NMN reactivates faltering blood flow According to a 2018 study published in the Cell journal, aging mice with a compromised blood flow experienced a reactivation of their blood flow after taking NMN. The researchers, led by Dr. David Sinclair, a co-director at Paul F. Glenn center at Harvard Medical School, found that as the body ages, the number and functions of endothelial cells (ECs) lining the blood vessels decline. This capillary decline affects the supply of nutrients, oxygen, exchange of heat, and removal of waste products. If nothing is done to stop or reverse this loss, it accelerates the aging process and along with it comes age-related complications. Have you found yourself struggling to exercise or wished you could last longer on a treadmill? Well, this is the reason behind the decline in strength and endurance you are experiencing as you age. However, all is not lost! The study found that NAD+ precursors such as NMN and nicotinamide riboside (NR) working through the Sirtuin Pathway, can help restore the capacity of endothelial cells to form new blood vessels. There you go, another reason to boost your NAD+ levels with NMN supplements! Most probably this supplement is already on the watch list of most professional sports teams in America because of its ability to enhance performance by boosting the blood flow. We all hope they get it fast before the World Anti-Doping Agency (WADA) comes knocking! NMN has been at the forefront in studies aimed at understanding and possibly reversing the aging process. The role of NMN as a precursor to NAD+ is critical in boosting longevity and we’ve listed many of its benefits above. But, here are two more ways NMN fights aging: NMN Suppresses age related weight gain. As people age, they gain weight. In a 2016 study, it was found that subjects given NMN saw their fat mass decrease and lean mass increase. By supplementing with NMN, you can lose weight and build muscle—two powerful ways to improve muscle health and look and feel younger! NMN Boost energy metabolism. By mediating the synthesis of NAD+, NMN helps in breaking the nutrients into energy, powering important cell functions and reducing oxidative stress. These biochemical processes slow down and potentially halt the aging process. NMN not only boosts your energy but helps in repairing your cells! Endurance and Muscle Strength Decreased physical endurance and muscle strength are often considered to be “inevitable” symptoms of the normal aging process. However, recent animal research indicates that NMN may prevent these declines in aging mice. In fact, one study found that consumption of NMN enhanced endurance and muscle strength in aged mice to such a degree that they became as healthy as their much-younger peers! Aging Endurance and muscle strength are not the only physical symptoms impacted by the aging process; body weight, energy metabolism, blood lipids, insulin sensitivity, and vision are also adversely affected by the aging process. Excitingly, NMN supplementation has been found to suppress age-associated weight gain, enhance metabolism, improve insulin sensitivity and plasma lipid levels, benefit vision, and prevent adverse alterations in gene expression in aging mice. These effects highlight the therapeutic potential of NMN as a beneficial anti-aging intervention for humans. Alzheimer’s Disease and Neurological Function Alzheimer’s disease is on the rise, with nearly 5.7 million Americans living with the disease; this number is projected to rise to 14 million by 2050. Dietary and lifestyle changes are crucial for preventing and slowing the progression of Alzheimer’s disease. NMN may help bolster the beneficial effects of dietary and lifestyle changes in Alzheimer’s disease prevention by preserving the health of the brain. NMN inhibits the buildup of amyloid-beta, an abnormal protein implicated in the adverse brain changes characteristic of Alzheimer’s disease, while also decreasing synaptic loss and brain inflammation. These effects slow down the process of brain degeneration and may even help reverse the progression of Alzheimer’s disease. The neurological benefits of NMN are not limited to Alzheimer’s disease; NMN also maintains the brain’s population of neural stem cells and attenuates brain injury after head trauma. These findings suggest that NMN may have significant therapeutic benefits for athletes who have suffered concussions, and other individuals recovering from head injuries. Heart Disease The human heart requires a continuous supply of ATP to fuel its muscular contractions and sustain life. Interruptions in the heart’s ATP supply can impair cardiac and vascular function and contribute to the development of cardiovascular disease. By enhancing the biosynthesis of NAD+, an essential substrate in ATP-producing reactions, NMN boosts cardiac ATP levels and significantly improves heart health. In fact, supplementation with NMN may even prevent myocardial infarctions and heart failure! Importantly, NMN also reduces arterial aging and vascular dysfunction, two phenomena that play crucial roles in the pathogenesis of cardiovascular disease. Diabetes and Metabolic Syndrome In pancreatic beta cells, NAD+ regulates insulin secretion in response to the ingestion of dietary glucose. NAD+ also governs insulin activity and glucose homeostasis in skeletal muscle, the liver, and adipose tissue. Research indicates that the normal biosynthesis of NAD+ is severely compromised in diabetic individuals, leading to insulin resistance and glucose intolerance. By restoring NAD+ levels in skeletal muscle, the liver, and adipose tissue, NMN improves insulin sensitivity and may help reverse the course of diabetes. NMN also corrects dyslipidemia, a condition in which cholesterol and triglycerides are elevated in the bloodstream. Dyslipidemia and insulin resistance are key features of metabolic syndrome, a disorder that afflicts a whopping 35 percent of U.S. adults and significantly increases the risk of diabetes, heart disease, and stroke. Finally, NMN normalizes the expression of genes that govern circadian rhythms and decreases oxidative stress and inflammation; altered circadian rhythms, oxidative stress, and chronic inflammation are three of the most important underlying causes of type 2 diabetes and metabolic syndrome. These fascinating findings indicate that NMN may play an essential adjunct role, alongside dietary and lifestyle changes, in the prevention and treatment of type 2 diabetes and metabolic syndrome. DNA Repair Your DNA serves as the blueprint for your body’s physiological function. When DNA expression goes awry due to factors such as an unhealthy diet, environmental toxins, and aging, your body’s blueprint is intrinsically altered; this disrupts normal body function and contributes to the development of chronic health conditions such as cancer, diabetes, and neurological dysfunction. NMN helps prevent adverse changes in gene expression by repairing damaged DNA. Weight Weight gain and weight loss resistance are common struggles for countless Americans. NMN is a powerful nutraceutical ally in weight loss efforts because it reverses insulin resistance, improves glucose tolerance, and ameliorates mitochondrial dysfunction, three factors that contribute to stubborn weight issues

 

 

 

ATP (adenosine triphosphate powder) 

Benefits Overview:

  • Increase Athletic Performance
  • Increase Muscular Excitability
  • Increase Blood Flow
  • Dramatically improve recovery time
  • Improved Oxygen & Nutrient delivery
  • Increase lean muscle mass and thickness
  • Clearance of metabolic Waste such as lactate
  • Anti-Aging properties
  • Improves Skin appearance and health
  • Reduces fatigue

is a new-generation nutraceutical which provides the body with the exact molecule it needs to produce energy (adenosine triphosphate or ATP), in the form and at the dose which research has shown to be effective. ATP is a major human metabolite which plays a crucial role - both at an intracellular level (energy-producing) and an extracellular level (regulating numerous physiological functions). ATP levels decrease inexorably with age (by around 50% between the ages of 20 and 70) - many older people complain of having less energy than when they were young. Adequate levels of ATP are essential for well-being, physical exertion and even for certain organs to function properly. Decreases in blood and plasma ATP pools, in particular, have a detrimental effect on blood pressure and vascular health. ATP has been shown to increase levels of ATP in red blood cells, plasma and organs, as effectively as injections. Such increases activate ATP receptors on vascular walls which relax and dilate them, enabling more blood to reach the heart, lungs and periphery, without increasing heart rate or blood pressure. The increases in ATP levels remain measurable for at least six hours. Several clinical studies have been carried out on ATP, enabling the following indications to be made for this product: To increase energy and vitality: supplementation with ATP restores energy levels, reduces fatigue and improves quality of life. ATP is the first nutraceutical to enable ATP levels in the body to increase without having to consume more food. Dr Rapaport, of Harvard and Boston Universities' Medical Schools, is an authority on the subject of ATP - he has studied it for 30 years, publishing over 50 scientific studies on its role in the body. To improve physical and athletic performance: ATP increases the availability of glucose, nutrients and oxygen in muscles. This allows faster removal of catabolic waste products which, in turn, improves both performance and recuperation while reducing the perception of fatigue and/or exercise-associated pain. ATP does not, however, appear on the list of banned substances. For anti-aging: by restoring youthful ATP levels, ATP improves circulation in general and in a non-stimulating way. ATP benefits the pulmonary and cardiovascular systems first, and subsequently all peripheral systems. By improving circulation to, and within the brain, ATP improves cerebral metabolism and mental acuity. A recent study also shows that oral administration of ATP significantly reduces pain associated with lumbar arthritis. ATP is produced by a proprietary fermentation process which conforms to GMP and ISO 9002 standards. As ATP is degraded by stomach acids, this product comes in gastro-resistant tablets designed to release the active principles exactly where they can be absorbed. Alongside this innovative formulation, other dietary supplements may also be of interest for maintaining general well-being. ATP can help maintain balanced and healthy thyroid function.

 

Dehydroepiandrosterone, better known as DHEA,

Benefits Overview:

  • Improve Sexual function
  • Boost Immune System Function
  • Naturally slows the aging process
  • Increase lean Muscle Mass while decreasing body fat
  • Increase energy levels
  • Increase Neurological Function and Memory
  • Improve bone & muscle strength
  • Improves general sense of well being
  • Improves the appearance of skin
  • Increases Testosterone Levels
  • Normalizes Estrogen Levels
  • Building up the adrenal gland
  • Improves symptoms of vaginal atrophy
  • Improves bone density to help treat Osteoporosis

is a steroid hormone. It is naturally synthesized by the body and performs a number of roles. It has been investigated widely for its possible therapeutic effects in a range of conditions. Sometimes called the “super hormone” and the “fountain of youth hormone,”. is also known as androstenolone, 3β-hydroxyandrost-5-en-17-one and 5-androsten-3β-ol-17-one. DHEA is one of the most abundant steroid hormones in the human body. It is produced by the adrenal glands, the gonads, and the brain. It is normally found in the form of dehydroepiandrosterone sulfate (DHEAS). The body holds DHEAS in reserve and converts it to specific hormones when needed. It is important for creating estrogen and androgen sex hormones and contributes to the development of so-called androgenic effects, or masculinization. Some say that DHEA enhances athletic performance. The World Anti-Doping Agency (WADA) prohibits its use in sporting competitions. Production of DHEA peaks when people are in their 20s and 30s, and then it declines. This is the main reason that DHEA is considered an important chemical in the aging process, and a potential target for anti-aging drugs. DHEA can act as a neurosteroid, directly affecting targets inside the brain. Its activities are not fully understood, but some researchers believe it helps protect neurons from toxins and after injuries, such as strokes. Some research suggests that it may contribute to nerve growth, and that it may help reduce inflammation and prevent cell death. It may also modulate mood. For this reason, it has been studied for the treatment of mood disorders, such as anxiety and depression. Research published in the journal Nature in 2013 found that DHEA enhanced connections between the amygdala and hippocampus and reduced activity levels in both regions. These changes are thought to contribute to an enhanced mood and a reduced memory for emotional events. Some studies have found that naturally higher levels of DHEA and DHEAS have a positive effect on some types of cognitive tasks. Over the last decade, DHEA has been studied for its effectiveness in treating a number of diseases and conditions. Success rates have varied. Some diseases cause a reduction in bone density. Some research suggests that artificially raising DHEA levels helps increase bone density, especially in women. However, not all studies have produced positive results. Depression has been linked to low blood levels of DHEA. There is evidence that DHEA could help relieve symptoms of depression. A review of research, published in 2014, suggested that DHEA might improve symptoms of depression in people with schizophreniaanorexia nervosaHIV, and adrenal insufficiency. However, the use of DHEA is not recommended with drugs commonly used to treat these conditions. Some evidence suggests that DHEA may help reduce weight in those taking the supplement. A review in 2013 concluded that “DHEA supplementation in can induce a significant positive effect on body composition.” A small study of 26 people with anorexia nervosa found that those who took 100 milligrams (mg) of DHEA supplements for 6 months saw an increase in body mass index (BMI) and also enhancements in mood. Adrenal insufficiency This happens when the adrenal glands do not produce enough steroid hormones, including DHEA. Supplementing with DHEA can reduce symptoms of adrenal insufficiency, but side effects can be substantial. Further evidence is needed to confirm its effectiveness overall. LUPUS This is an autoimmune disorder affecting the skin and organs. DHEA levels are lower than normal in women with lupus. Some research shows that DHEA improves a number of lupus symptoms. Sexual Function Some studies suggest DHEA may help people with deficits in sexual function, libido, and erectile dysfunction. Aging Evidence that DHEA supplements could help stave off age-related changes is also very prevalent. There may also be side effects, such as a reduction in “good” HDL cholesterol and heart palpitations. HIV Some studies have suggested that DHEA might help prevent replication of the HIV virus and bolster the immune system, but the authors of at least one study, published in 2007, found that it did not have these effects. Cervical Cancer Results of laboratory investigations suggest that DHEA may inhibit the proliferation of cervical cancer cells, and that it could protect against the migration of cancer cells. Muscle Strength, in every study conducted, athletes have all seen positive gains in muscle strength and repair capabilities..

 

 

Diindolylmethane (DIM)

Benefits Overview:

  • Boost Immune System (prevention of certain types of cancers)
  • Suppresses/Normalizes Estrogen levels
  • Increased weight loss
  • Promotes body detoxification
  • Helps clear acne and appearance of skin
  • Reduce hot flashes and hormonal surges
  • May relieve PMS symptoms

is a compound created when you digest cruciferous vegetables, such as broccoli or Brussels sprouts. DIM supplements are being studied for their protective effects against certain cancers. They’re also used to help prevent prostate enlargement, treat acne, aid weight loss, and reduce premenstrual syndrome (PMS) and menopause symptoms. While these benefits are promising, overall research on DIM’s effectiveness and long-term safety in humans is limited. ANTI-CANCER properties. Test-tube and animal studies suggest that DIM supplements may help prevent the growth and spread of breast cancer cells. However, human studies are limited. A yearlong study gave 130 women with breast cancer on tamoxifen therapy either a placebo or 150 mg of DIM twice a day. DIM supplements resulted in a significantly improved ratio of two types of estrogen — 2-hydroxyestrone and 16-hydrozyestrone. Although research is ongoing, increasing the ratio of 2-hydrozyestrone to 16-hydrozyesterone may reduce breast cancer risk and cause anti-tumor effects . A 30-day study in 19 post-menopausal women with early-stage breast cancer found that taking 108 mg of DIM per day also resulted in beneficial changes in estrogen levels. Test-tube and animal studies indicate that DIM protects against ovarian, prostate, and colon cancers as well. All the same, human studies are needed. Notably, a mouse study found that DIM helped prevent cervical cancer. However, in a 6-month study in 551 women with cervical abnormalities, taking 150 mg of DIM per day had no effect on cervical cell changes. PROSTATE PROTECTION. DIM supplements may safeguard against prostate enlargement and prostate cancer. In fact, it may help combat prostatic intraepithelial neoplasia (PIN), a condition that’s characterized by prostate cell growth and considered to be a precursor to prostate cancer. In a 12-month study, 21 men with high-grade PIN were given either a placebo or 900 mg of DIM per day. Those given DIM experienced significant improvements in prostate health, as well as PIN. Test-tube and animal studies likewise suggest that DIM helps fight prostate cancer. Still, more human research is necessary. WEIGHT LOSS. Given that estrogen plays an important role in regulating fat accumulation, DIM supplements may aid weight loss — although no human research currently supports this effect. All the same, studies link an imbalance of estrogen — either too much or too little — to an increased risk of weight gain in both men and women. Furthermore, DIM supplements may stimulate fat breakdown and inhibit fat cell formation. In one study in mice on a high fat diet, 23 mg of DIM per pound (50 mg per kg) of body weight significantly reduced the formation of new fat cells. DIM supplements are purported to aid other hormone-related conditions. Still, it’s important to remember that research is lacking on all of these effects. May fight acne. DIM supplements are sometimes used to treat hormonal acne. However, no research currently supports this use. May reduce hot flashes. Hot flashes during menopause likely result from hormonal changes. While DIM supplements are used to reduce hot flashes, their effectiveness isn’t supported by research. May relieve PMS symptoms. PMS symptoms are thought to be due to monthly changes in estrogen levels. Again, some people use DIM supplements to reduce symptoms, but research hasn’t confirmed their effectiveness. May correct estrogen imbalances in men. High levels of estrogen in men are linked to breast growth, erectile dysfunction, and infertility.

 

NIACIN (Vitamin B3):

Benefits Overview:

  • Lower Cholesterol
  • Ease Inflammation and Arthritis
  • Boost Brain Function and memory
  • Improve skin appearance
  • Boost sense of well being
  • Increase energy
  • Improve Heart Health & fight Heart Disease
  • May Help to treat Type 1 Diabetes
  • Treats Pellagra

Niacin, also known as vitamin B3, is an important nutrient. In fact, every part of your body needs it to function properly. As a supplement, niacin may help lower cholesterol, ease arthritis and boost brain function, among other benefits. Niacin is one of the eight B vitamins, and it’s also called vitamin B3. There are two main chemical forms and each has different effects on your body. Both forms are found in foods as well as supplements. Nicotinic acid: As a supplement, nicotinic acid is a form of niacin used to reduce cholesterol levels and lower your risk of heart disease. Niacinamide or nicotinamide: Unlike nicotinic acid, niacinamide doesn’t lower cholesterol. However, it may help treat psoriasis and reduce your risk of non-melanoma skin cancer. Niacin is water-soluble, so your body doesn’t store it. This also means that your body can excrete excess amounts of the vitamin if it’s not needed. Your body gets niacin through food but also makes small amounts from the amino acid tryptophan. 1. Lowers LDL Cholesterol Niacin has been used since the 1950s to treat high cholesterol. In fact, it can lower levels of “bad” LDL cholesterol by 5–20%. However, niacin is not the primary treatment for high cholesterol due to its possible side effects. Rather, it’s primarily used as a cholesterol-lowering treatment for people who can’t tolerate statins. 2. Increases HDL Cholesterol In addition to lowering “bad” LDL cholesterol, niacin also raises “good” HDL cholesterol. Studies show that niacin raises HDL levels by 15–35%. 3. Lowers Triglycerides Niacin can also lower triglycerides by 20–50%. It does this by stopping the action of an enzyme that’s involved in triglyceride synthesis. Consequently, this lowers the production of both LDL and very low-density lipoprotein (VLDL). Therapeutic doses are needed to achieve these effects on cholesterol and triglyceride levels. 4. May Help Prevent Heart Disease Niacin’s effect on cholesterol may help prevent heart disease — but newer research suggests an additional mechanism by which it benefits your heart. It can help reduce oxidative stress and inflammation, both of which are involved in atherosclerosis, or the hardening of your arteries. Some research indicates that niacin therapy — either alone or in combination with statins — could help lower the risk of health problems related to heart disease. 5. May Help Treat Type 1 Diabetes Type 1 diabetes is an autoimmune disease in which your body attacks and destroys insulin-creating cells in your pancreas. There’s research to suggest that niacin could help protect those cells and possibly even lower the risk of type 1 diabetes in at-risk children. However, for people with type 2 diabetes, the role of niacin is more complicated. On the one hand, it can help lower the high cholesterol levels that are often seen in people with type 2 diabetes. On the other, it has the potential to increase blood sugar levels. As a result, people with diabetes who take niacin to treat high cholesterol also need to monitor their blood sugar carefully. 6. Boosts Brain Function Your brain needs niacin — as a part of the coenzymes NAD and NADP — to get energy and function properly. In fact, brain fog and even psychiatric symptoms are associated with niacin deficiency. Some types of schizophrenia can be treated with niacin, as it helps undo the damage to brain cells that occurs as a result of deficiency. Preliminary research shows that it could also help keep the brain healthy in cases of Alzheimer’s disease. However, results are mixed. 7. Improves Skin Function Niacin helps protect skin cells from sun damage, whether it’s used orally or applied as a lotion. Recent research suggests it may help prevent some types of skin cancer as well. One study found that taking 500 mg of nicotinamide — a form of niacin — twice daily reduced rates of non-melanoma skin cancer among high-risk individuals. 8. May Reduce Symptoms of Arthritis In one preliminary study, niacin helped ease some symptoms of osteoarthritis, improving joint mobility and reducing the need for nonsteroidal anti-inflammatory drugs (NSAIDs) . Another study in lab rats found that an injection with the vitamin reduced inflammation related to arthritis. Although this is promising, more research is needed. 9. Treats Pellagra Severe niacin deficiency causes a condition called pellagra. Thus, taking a niacin supplement is the main treatment for pellagra. Niacin deficiency is rare in industrialized countries. However, it may occur alongside other diseases, such as alcoholism, anorexia or Hartnup disease.

 

CREATINE HCL: BENEFITS OF CREATINE HCL: 

Benefits Overview:

  • Helps muscle cells produce more energy
  • Raise Growth Factor 1 (IGF1) to increase muscle mass
  • Muscle cell volumization
  • Decreases Myostatin Levels (Grow past your genetic limitations)
  • Improve Muscle Performance (strength, endurance, power, recovery)
  • Speed Muscle Growth
  • May help in treating Parkison’s Disease
  • Improve Motor Function
  • May lower blood sugar levels to fight Diabetes
  • Improves Brain Function
  • Reduces fatigue and tiredness

 

Experts consider the HCL form of creatine to be most soluble, most  bioavailable and most absorbent creatine on the market today when  compared to creatine monohydrate. This means that creatine HCL is a super concentrated form of creatine and a much smaller dose is  needed to achieve the same effect in regards to strength and muscle  gain. Micro-dosing means only having to take ¼ tsp per 100 lbs  bodyweight once per day! Taking this small amount eliminates the  need to drink large quantities of liquid. The benefit of taking Creatine HCL is there’s no loading phase, no  cycling on and off, no bloating and no water retention. Some people  experience mild side effects when using creatine monohydrate, such as  bloating, cramping and frequent urination. Although uncommon, and  not detrimental to health, these side effects can be a nuisance.  Creatine HCL has been said to eliminate these issues. In order to be  most effective for taking Creatine Monohydrate, it is often  recommended that a “loading phase” in which large does (20g/day)  is to be consumed. Due to the higher bioavailability and absorption  of creatine HCL, this loading and cycling phase is not necessary.  WHAT IS CREATINE? Creatine is naturally found in the body. It stores the essential source  of energy (ATP) for all your muscles. The more volumization of  creatine in your muscle, the more energy (ATP) your muscle has,  which translates into more muscular powder and endurance,  which means better endurance, strength and recovery during your  workouts. WHY TAKE CREATINE? Creatine enhances the body’s capacity to perform high intensity  work while assisting greater muscle size and performance gains as  a result. Creatine enhances recovery Creatine is shown to enhance complete recovery from intense exercise Creatine enhances muscle volumization Creatine causes muscle cells to inflate, which produces a more  heavily muscled appearance an important benefit to bodybuilders and athletes. Increased strength and power, Increased muscle mass, Increased fat loss, Improved recovery and Improved sports performance

 

HMB: Hydroxy Beta Methylbutyrate Monohydrate::

Benefits Overview:

  • Increase lean body mass
  • Improve athletic performance
  • Decrease body fat (aids in fat metabolism)
  • Lower Cholesterol
  • Lower Blood Pressure
  • Protects against heart disease
  • Boost stamina
  • Improves recovery time from exercise
  • Increase strength
  • Reduces muscle protein breakdown
  • Decreases muscle discomfort after training

 

 

 DISCOVER THE SCIENCE BEHIND HMB 50 HUMAN STUDIES, 40 REVIEW ARTICLES AND 4 META-ANALYSES Calcium HMB (calcium β-hydroxy β-methylbutyrate monohydrate), is a nutritional supplement with over 94 published, peer-reviewed clinical studies proving its safety and efficacy to: Increase strength gains from resistance training. Boost body fat loss and optimize body composition. Reduce muscle protein breakdown Decrease muscle discomfort resulting from exercise. Improve recovery after resistance and endurance training. Boost muscle protein synthesis. Maintain lean muscle during calorie restriction. Typical weight loss strategies reduce both fat and lean body mass, shifting the body into an energy storage mode that can inhibit weight loss progress. HMB is the only ingredient proven to decrease muscle protein breakdown, protecting muscle mass while enhancing fat loss. Found in grapefruit, cauliflower, red meat, catfish, and other foods, HMB is a breakdown product of the amino acid leucine. Your body produces it naturally from proteins containing leucine. Since its introduction in 1995, the supplement form of HMB has received a lot of press in some fitness magazines for its presumed fat-burning and muscle-building benefits. Scientists believe HMB prevents muscle breakdown and aids in fat metabolism. Many animal studies have been conducted on HMB, and most have shown that supplementation does two things: It increases lean tissue, and it enhances the immune system. These findings have prompted the use of HMB as an additive in animal feed. There have been a few studies published in scientific journals on the effects of HMB supplementation in humans. At the University of Iowa, researchers conducted two related studies on HMB. In the first, forty-one men were given 1.5 or 3 grams of HMB, or a placebo, daily while participating in a strength-training program 3 days a week. By the end of 3 weeks, the HMB-takers had gained 63 percent more strength than the others. Plus, muscle breakdown during exercise was minimized among the HMB-supplemented group. In the second study, twenty-eight volunteers took either 3 grams of HMB or a placebo, and strength-trained 6 days a week for 7 weeks. By the end of the study period, the HMB-takers had lost twice as much body fat as those taking the placebo. In another study, female athletes who took 3 grams of HMB daily boosted their strength by 7 percent, compared with a placebo-supplemented group. HMB may increase endurance, too. In one experiment, cyclists in-creased their performance and training intensities dramatically while supplementing with HMB for 2 weeks. Based on this collection of studies, HMB appears to increase muscle mass and strength, prevent muscle breakdown, support fat loss, and possibly boost stamina. The research certainly gives high marks to HMB, and I think you'll see a lot more studies on HMB in the future.

 

 

 

Conjugated Linoleic Acid (CLA)

Benefits Overview:

  • Supports health fat/weight loss
  • Enhance Muscle density & lean mass
  • Improves Heart health
  • Improves Immune System Function
  • Increases metabolism

is a polyunsaturated fat found in linoleic acid, an essential fatty acid found mostly in plant oils. Naturally, CLA is a product of digestion by microbes in the first stomach (rumens) of grass-eating animals such as cows, so is found mainly in grass-fed beef and dairy products. Not only is CLA an easy way to lose weight, it’s also connected to fighting cancer, and helping your body build muscle rather than store fat. Conjugated linoleic acid is an omega-6 fatty acid. Diets high in omega-6 tend to be inflammatory, which is why you may have heard to avoid omega-6 rich foods. Your body actually needs some omega-6 from food sources, but in a much smaller dose than the standard American diet dishes out. RelatedLearn Your Lipids: A Quick Guide to Healthy Fats Fortunately, the anti-inflammatory properties of CLA cause it to behave more like an omega-3 in the body. The two main active isomers, or types, of CLA are the 9,11 isomer, and the 10,12 isomer, both naturally found in CLA-rich foods. Say it with me: Butter burns fat! The most well-established benefit of CLA is its fat-fighting power. Successful human studies show that doses of 3 to 4 grams daily build muscle mass and promote body fat loss in healthy, overweight, and obese participants. Conjugated linoleic acid can affect your weight loss through several pathways. Several studies show that the 10,12 CLA isomer acts on PPAR-gamma receptors to inhibit the genes responsible for fat storage and adipocyte (fat cell) production, preventing weight gain from the start. (Bonus points: reducing fat storage also boosts your liver performance, and can reduce the fatty deposits behind atherosclerosis.) At the same time, CLA increases your body’s energy expenditure, helping you to burn fat faster than you build it. Human studies also show that CLA can increase satiety (your feeling of fullness). The theory here is that 10,12 CLA actually decreases the expression of certain hunger-signalling factors in the hypothalamus area of your brain. The anti-inflammatory functions of conjugated linoleic acid, like other inflammation-busting foods, help it support nearly every system in your body. Studies show that CLA plays a role in regulating your body’s inflammatory and immune responses, as well as boosting liver health to support detoxification. Conjugated linoleic acids bolster the immune system and helps build resistance to infections, inflammatory disorders and other immune system imbalances like autoimmune disease and allergies. In one study from The Journal of Nutrition, the anti-inflammatory properties of both CLA isomers successfully reduced inflammation in arthritic mice. It may also benefit people suffering from asthma and allergies by reducing over-responsive airway inflammation. These results suggest that consuming CLA could benefit other chronic inflammatory conditions. One of the first findings to bring conjugated linoleic acid into the health scene was its potential as a cancer prevention agent, especially in the fight against breast cancer. In animal studies, supplementing with CLA reduced the number of tumors in rats. It directly limited the process of cancer formation by lowering the susceptibility of tissues to cancer, and inhibiting the metastasis (spreading) and adhesion of new tumors. This cancer-busting fatty acid has also been shown to reduce the formation of new blood vessels needed to feed a tumor, and up-regulate a gene called PTP gamma, known for its role in suppressing tumors in breast, kidney and lung cancer. A study in the American Journal of Clinical Nutrition found higher concentrations of 9,11 CLA  in adipose tissue was associated with a lower risk of diabetes. Of course, if you’re eating a diet rich in CLA, you’re probably eating less of the toxic processed meat products linked to diabetes. Many supplements or health sites may lead you to believe that CLA improves insulin response and blood sugar control, however the science behind this claim falls short. In fact, many trials show that in high doses, isomer 10,12 CLA may actually increase insulin resistance, where 9,11 appears to have no effect. One interesting study showed that supplementing CLA together with olive oil kept the benefits, but prevented the insulin resistance seen from CLA supplementation alone![18] By keeping sugar swings low, a low-glycemic diet may also help you to safely reap the other dietary benefits of CLA. Another advantage of CLA comes from its bone-strengthening and protective effects. Dietary CLA significantly prevents losses in bone density by both increasing the body’s signals to absorb calcium (parathyroid hormone and calcitriol), as well as reducing the activity of osteoclasts, the cells responsible for eating away at your bones when calcium is low. Who knew that butter could bust osteoporosis.

 

GLUTAMINE

Benefits Overview:

  • Improves Gastrointestinal Health
  • Helps leaky gut and ulcers
  • Boosts Brain Health
  • Improves IBS and Diarrhea
  • Promotes Muscle Growth
  • Decreases muscle wasting
  • Improves Athletic Performance
  • Improves recovery times
  • Decreases soreness and inflammation from training
  • Burns fat
  • Improves insulin sensitivity to help support type 2 Diabetics

 

glutamine is one of 20 naturally occurring amino acids in dietary protein. In fact, L-glutamine is the most abundant amino acid in the bloodstream and makes up 30–35 percent of the amino acid nitrogen in your blood. It’s actually known as a conditionally essential amino acid because your body uses it in large amounts. What does ‘conditionally essential amino acid’ mean? It refers to the amino acid becoming essential when the individual faces disease or specifically muscle wasting, which can happen in the course of certain diseases or even physical trauma. It also becomes a conditionally essential nutrient during certain catabolic states, including after bone marrow transplantation. Found in both animal and plant proteins, it’s also available in supplement form and is widely popular in the fitness community and beyond. It’s found in high levels in both casein and whey protein. It’s important to know that the majority of people don’t get enough L-glutamine from their food alone. That’s why supplementing your diet with it is an excellent way to boost your immune system and improve your ability to fight infection and diseases. In fact, it’s become a common supplement for critically ill patients. According to a study published in the medical journal Critical Care, glutamine dipeptide-supplemented parenteral nutrition “continues to be associated with a significant reduction in hospital mortality and hospital length of stay.” Amazingly, around 60 percent of your skeletal muscle is made up of glutamine – and supplementing with this amino acid can aid protein synthesis and help naturally balance your pH levels. New research is now showing that L-glutamine benefits the body in the following ways: 1. Improves gastrointestinal health L-glutamine benefits your health if you have any type of digestive issue, such as irritable bowel syndrome (IBS), an inflammatory bowel disease like Crohn’s disease, ulcerative colitis, diverticulosis, diverticulitis, leaky gut or any of the issues associated with leaky gut (like joint pain, rosacea or any type of autoimmune response). Because it’s a vital nutrient for the intestines to rebuild and repair, you need this amino acid in your diet on a regular basis. It’s worth noting that the man famous for discovering the Krebs cycle in the body (also known as the “citric acid cycle“) was the first person to recommend taking L-glutamine for gut-related issues. That’s because Sir Hans Adolf Krebs — a German-born British biochemist who received (with Fritz Lipmann) the 1953 Nobel Prize for Physiology — found that it helped improve a healthy gut-related immune response. And additional research supports this finding. A study published in the journal of Clinical Immunology found that L-glutamine normalizes the effects of the TH2 immune response that stimulates inflammatory cytokines. The effects of L-glutamine in these studies show that it reduces intestinal inflammation and can help people recover from food sensitivities. 2. Helps leaky gut and ulcers There are millions of people struggling with a condition called leaky gut syndrome, which is essentially the main cause of autoimmune disease today. Leaky gut can cause thyroid issues like Hashimoto’s disease; it also contributes to arthritis, skin issues like psoriasis and other serious health issues. Because glutamine is the major fuel source for cells of the small intestine, it has been shown to heal leaky gut in clinical studies. A study published in the medical journal Lancet examined 20 hospital patients and found that supplementing with L-glutamine decreased intestinal permeability. An animal study published in the British Journal of Surgery found that L-glutamine benefits ulcerative colitis and inflammatory bowel disease. It can also help heal ulcers by acting protection from further damage, plus offers a healthier, natural alternative to antibiotics for the treatment of stomach ulcers. If you’re unsure if you suffer from leaky gut, take my leaky gut test. If, indeed, you appear to have leaky gut, L-glutamine is the No. 1 amino acid you need to help heal and repair it. 3. Boosts brain health A precursor to the neurotransmitter glutamate in your brain, glutamine is key to boosting your brain health. Why? A disruption of the glutamine-glutamate cycle can result in all kinds of brain problems, including Reye’s Syndrome, epilepsy, bipolar disorder, schizophrenia, anxiety, depression and alcohol addiction. Glutamine can also help stall brain aging. Mitochondrial dysfunction causes abnormal increases in the neurotransmitter glutamate and, again, puts the brain at risk for developing the above problems. A study conducted at the New York University School of Medicine showed that even mild traumatic brain injury caused brain atrophy, and most of this damage was due to the disrupted glutamine-glutamate cycle and an abnormal increase in glutamate levels. 4. Improves IBS and diarrhea Glutamine helps improve IBS and diarrhea by balancing mucus production, which results in healthy bowel movements. If you have Hashimoto’s or an underactive thyroid, it should be a part of your hypothyroidism diet. If you suffer from IBS symptoms like constant diarrhea or ulcerations, it needs to be part of your IBS diet. 5. Promotes muscle growth and decreases muscle wasting Whether your goal is to increase athletic performance, boost metabolism, improve recovery or even build muscle, research shows that L-glutamine can significantly aid your efforts. During an intense workout, your body becomes stressed and your muscles and tendons require more glutamine than the amount supplied by a normal diet. So, after an intense workout, the levels of cellular glutamine can drop by 50 percent and plasma levels by 30 percent! This muscle-wasting state is a gateway for the body to use your muscle for energy rather than carbohydrates. But glutamine can prevent this from happening. Supplementing with L-glutamine allows your muscles to fight and push a bit further, which boosts your strength and helps repair your skeletal muscles. A study found that glutamine supplementation makes it possible to recover quicker from intense weight training sessions because it improves muscle hydration. This aids the muscle recovery process and reduces recovery time for wounds and burns. It’s why glutamine supplementation is not only common for bodybuilders in the bodybuilding industry, but in nearly every athletic pursuit these days. Replenishing glutamine levels after an intense session could take up to five days, so it is important to take it on a regular basis if you are doing intense exercise. Some bodybuilders say that glutamine works best when combined with certain brained chain amino acids (BCAAs), especially leucine. Others consume it post-workout with creatine in order to try to improve muscle recovery and restore the body’s energy stores. 6. Improves athletic performance and recovery from endurance exercise One of L-glutamine’s main roles in the body is to support detoxification by cleansing the body from high levels of ammonia. It acts as a buffer and converts excess ammonia into other amino acids, amino sugars and urea. Doing approximately one hour of exercise can cause a 40 percent reduction of glutamine in the body. It can also cause suppressed immune function. This has a negative impact on your resistance training and may lead to overtraining syndrome. L-glutamine benefits long distance athletes as well by boosting the immune system (T-helper cells). Animal studies have indicated that this increase in T-helper cells may reduce the ‘stresses’ associated with overtraining syndrome. 7. Burns fat and improves diabetes Research has indicated that HGH levels are up by nearly 400 percent after glutamine supplementation. This hormonal response leads to an increase in resting metabolic rate and improves the after-burn effect or EPOC post-exercise. This afterburn effect is essential for burning fat, weight loss and building lean muscle mass. L-glutamine also burns fat and builds lean muscle mass by helping suppress insulin levels and stabilize blood glucose. This enables the body to use up less muscle mass to maintain blood sugar and insulin sensitivity in the cells. In fact, six weeks of supplementation with 30 grams per day of glutamine powder “markedly improved some cardiovascular risk factors, as well as body composition, in patients with type 2 diabetes.” For this reason, L-glutamine benefits diabetics and those with sugar and carb cravings as well.

 

 

L-LEUCINE

Benefits Overview:

  • Increased Brain function
  • Post Exercise Recovery
  • Improved motor skills
  • Protects against liver cancer
  • Increased Exercise Performance
  • Reduces muscle wasting
  • Increased strength
  • Reduces cirrhosis of the liver
  • Protects and Improves Kidney Function
  • Increases protein synthesis
  • Decrease in body fat
  • Anti-Aging properties
  • Increases Energy

 

 

L-VALINE

Benefits Overview:

  • Improves Athletic Performance
  • Rapid workout recovery
  • Improves endurance
  • Increases lean muscle mass
  • Healthy Digestive Function

 

 

L-ISOLEUCINE

Benefits Overview:

  • Increases athletic performance
  • Increased protein synthesis
  • Blood Sugar Regulation
  • Lowers Glucose
  • Decreases Muscle Soreness
  • Reduce Fatigue